Simone DELLACQUA
Associate Professor
Research Activities
Research activities focus on the study of the interaction between metals (mainly copper and heme iron) with peptides of neuronal interest and involved in neurodegenerative diseases (amyloid-β peptide, α-synuclein, tau, prion peptides). The main goal is to study the binding of the metals in different oxidation states to these proteins and the reactivity of the relative complexes in oxidative reactions. A further line of research concerns the development of new porphyrinoid systems as bioinspired catalysts in oxygen activation and ROS regulation.
Expertise
kinetics; UV-Vis; NMR; Kinetic studies with particular interest in oxidative reactions promoted by metal complexes. Spectroscopic characterization (UV-Vis NMR CD) of metal-peptide complexes. HPLC-MS studies of oxidative modifications of peptidesCD; HPLC-MSResearch Areas
Metal-binding Peptides in Health Catalysis & Artificial MetalloenzymesAffiliations
- Department of Chemistry-University of Pavia Pavia, Italy